Key features and details
DCAMKL1 (Clone#JA11-03)
DCAMKL1 Recombinant Rabbit Monoclonal Antibody [JA11-03]
Tested Application :WB, IHC-P, IF-Cell, FC
Species Reactivity: human, mouse, rat
Catalog# BA0006
Product Name: Anti-DCAMKL1 Antibody (Clone#JA11-03)
Gene Name: DCAMKL1
Source: Rabbit
Clonality: Monoclonal
Isotype: IgG
Species Reactivity: human, mouse, rat
Tested Application: WB, IHC-P, IF-Cell, FC
Contents: 1ug/ul in 1×TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Immunogen: Synthetic peptide within Human DCAMKL1
Concentration: 1ug/ul
Purification: Protein A affinity purified
Observed MW: 82 kDa
Document
Storage
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
| Product size | 1 ml, 100 µl, 50 µl |
|---|
Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, manifesting as severe mental retardation. Genetic analysis has identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 displays sequence homology to β-subunits of heterotrimeric G proteins, and doublecortin contains a consensus Abl phosphorylation site. In addition, the DCAMKL1 (doublecortinlike and CAM kinase-like 1) protein shows homology to doublecortin. All three proteins are highly expressed in developing brain and may function together to regulate microtubules involved in neuronal migration. The DCAMKL1 protein encodes a functional kinase that is capable of phosphorylating myelin basic protein and itself, but its kinase activity does not appear to affect its microtubule polymerization activity.
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