Key features and details
Phospho-Nrf2 (Clone# SU0334)
Phospho-Nrf2 Recombinant Rabbit Monoclonal Antibody [SU0334]
Tested Application : WB，IHC-P，IF-Cell，IF-Tissue，FC，IP
Species Reactivity : Human
Catalog# BA0029
Product Name：Anti-Phospho-Nrf2 Antibody (Clone# SU0334)
Gene Name：Phospho-Nrf2
Source：Rabbit
Clonality：Monoclonal
Isotype：IgG
Species Reactivity：Human, Rat
Tested Application：WB, IF-Cell, IF-Tissue ,IHC-P, FC,IP
Contents：1ug/ul in 1×TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Immunogen：Synthetic phospho-peptide corresponding to residues surrounding Ser40 of Human Nrf2 aa 20-69 / 605.
Concentration：1ug/ul
Purification：Protein A affinity purified
Observed MW：Predicted band size: 68 kDa
Document
Recommended Dilution Ratios
|
Application |
Dilution Ratios |
|
WB |
1:1,000-1:5,000 |
|
IF-Cell |
1:50-1:250 |
|
IHC-P |
1:200-1:1,000 |
|
IF-Tissue |
1:50-1:200 |
|
IP |
Use at an assay dependent concentration |
|
FC |
1:50-1:100 |
Storage
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
| Product size | 1 ml, 100 µl, 50 µl |
|---|
RAC(Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains. It is commonly referred to as PKB, or by both names as “Akt/PKB”. The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
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